Antibody Cross-Reactivity in Antivenom Research

Flavivirus-induced antibody cross-reactivity

Dengue viruses (DENV) cause countless human deaths each year, whilst West Nile virus (WNV) has re-emerged as an important human pathogen. There are currently no WNV or DENV vaccines licensed for human use, yet vaccines exist against other flaviviruses. To investigate flavivirus cross-reactivity, sera from a human cohort with a history of vaccination against tick-borne encephalitis virus (TBEV),...

antigenic cross-reactivity anti-birtoxin antibody against androctonus crassicauda venom

background : antivenom is still widely used in the treatment of envenomation as there are no vaccines or other effective agents available against animal venoms. recently, neurotoxins named birtoxin family have been described from parabuthus transvaalicus and androctonus crassicauda. the aim of the present study was to test the antibirtoxin antibodies for their ability to neutralize the lethal e...

Cross-Reactivity and Neutralization Capacity of Polyspecific Antivenom Produced by Razi Institute against Three Species of Buthidea Family Scorpions

Immunological Cross-Reactivity and Neutralisation of European Viper Venoms with the Monospecific Vipera berus Antivenom ViperaTAb

Medically important cases of snakebite in Europe are predominately caused by European vipers of the genus Vipera. The mainstay of snakebite therapy is polyclonal antibody therapy, referred to as antivenom. Here we investigate the capability of the monospecific V. berus antivenom, ViperaTAb®, to cross-react with, and neutralise lethality induced by, a variety of European vipers. Using ELISA and ...

The Cross-reactivity and Transfer of Antibody in Transplantation Immunity

A close inomunochemical relationship of Forssman-type antigens in cells or in a methanol extract of guinea pig kidneys, lymph nodes, and platelets, of horse kidneys, and of sheep erythrocytes was demonstrated by complement-fixation, agglutination, and inhibition of hemolysis. The dissociation of antibody from several cross-reacting complexes and re-association with antigens of erythrocytes used...